profile photo of Manisha Saini

Manisha Saini

Postdoctoral Associate
CABM, 202
Arnold Lab

Education

B.Tech Biotechnology, Amity University, Noida, India, 2012
M.Tech Biotechnology, Amity University, Noida, India, 2014
Ph.D. Biochemistry, University of Delhi, 2022

Bio

Dr. Saini is a young Scientist. She received her Ph.D. in Biochemistry from Department of Biochemistry, University of Delhi, India in February 2022. She made significant contribution in the area of drug discovery by identifying and designing potential drug like candidates against a therapeutic enzyme DBH to circumvent hypertension. In addition, she also identified and validated a new drug target ARL15 in association to Rheumatoid arthritis.

In May 2022, Dr. Saini was recruited to join as a postdoctoral associate in the lab of distinguished Prof. Eddy Arnold at CABM, Rutgers and is working on unravelling the diverse complex structures of viruses.

Research Focus

Structure function relationship of viral proteins with a special emphasis on RNA-dependent RNA polymerase of flavivirus (DENV, YFV, WNV, ZIKV) and enterovirus (A71, D68)

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ASBMB 2022 Graduate/Postdoctoral Travel Award (2022) at the Experimental Biology; Pennsylvania Convention Center, Philadelphia, PA, USA.

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K.K Devendra oration award (2020) at the International Conference of Cardiovascular Sciences-2020 (ICCS-2020); Delhi Pharmaceutical Science and Research University (DPSRU), New Delhi, India.

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First prize in oral presentation (2020) at the International Conference on Frontiers in biochemistry and biotechnology strategies to combat human diseases; Shivaji College, University of Delhi, New Delhi, India. 

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Best poster award (2019) at International conference on Proteomics for System Integrated Bio-Omics, One Health and Food Safety; ICAR-National Dairy Research Institute, Karnal, India. 

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C.C Kartha Travel Award (2019) at NIMHANS Convention Centre; International Academy of Cardiovascular Sciences-India Section, Bangalore, India.

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Third prize in oral presentation (2018) at Cardiovascular Research Convergence; AIIMS and ICGEB, New Delhi.

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Second prize in poster presentation (2018) at UGC-SAP Symposium on strategies for insight, detection and intervention of human diseases; University of Delhi, New Delhi, India.

Patents

A furan-based anti-rheumatoid arthritis composition. Kundu, S., Saini, M., Thelma B. K., Dey, S. K, Arya, R., Provisional Indian Patent Application No. 202121026835, filled on 16.06.2021

A novel anti-hypertensive cardio-protective composition", Kundu, S., Dey, S. K., Thelma B. K., Kovuru, G., Maulik S. K., Prabhakar P., Saini, M., Provisional Indian Patent Application No. 20181100589, 16/02/2018, CAP Filed on 12/02/2019

Member of American Society for Biochemistry and Molecular Biology, and International Academy of Cardiovascular Sciences

Kumar G, Saini M, Kundu S. Therapeutic enzymes as non-conventional targets in cardiovascular impairments: A comprehensive review. Canadian journal of physiology and pharmacology. 2022;100(3):197-209. doi:10.1139/cjpp-2020-0732.
Dey S, Saini M, Dhembla C, et al. Suramin, penciclovir, and anidulafungin exhibit potential in the treatment of COVID-19 via binding to nsp12 of SARS-CoV-2. Journal of biomolecular structure & dynamics. 2021:1-17. doi:10.1080/07391102.2021.2000498.
Sharma A, Saini M, Kundu S, Thelma B. Computational insight into the three-dimensional structure of ADP ribosylation factor like protein 15, a novel susceptibility gene for rheumatoid arthritis. Journal of biomolecular structure & dynamics. 2020:1-16. doi:10.1080/07391102.2020.1860826.
Dey S, Saini M, Prabhakar P, Kundu S. Dopamine β hydroxylase as a potential drug target to combat hypertension. Expert opinion on investigational drugs. 2020;29(9):1043-1057. doi:10.1080/13543784.2020.1795830.
Misra S, Saini M, Ojha H, Sharma D, Sharma K. Pharmacophore modelling, atom-based 3D-QSAR generation and virtual screening of molecules projected for mPGES-1 inhibitory activity. SAR and QSAR in environmental research. 2017;28(1):17-39. doi:10.1080/1062936X.2016.1273971.
Saini Google Scholar