Education

B.Sc. (First Class) Pharmacology, University of Leeds, 2008
D.Phil. (Ph.D.) University of Oxford, 2015

Bio

Conor McClenaghan is an Assistant Professor in the Dept. of Pharmacology and the Dept. of Medicine at Robert Wood Johnson Medical School, and a resident faculty member at the Center for Advanced Biotechnology and Medicine. He trained as a postdoc at Washington University in St Louis with Colin Nichols, where research focused on molecular dysfunction and cardiovascular pathophysiology in genetic diseases arising from mutations in ATP-sensitive potassium (KATP) channels. Prior to this, he received a Ph.D. from the University of Oxford, UK, where he studied the structure and function of the TREK subfamily of K2P potassium channels which are integral to temperature and touch sensation, and critical determinants of pain sensing. Research in the McClenaghan lab focuses on the molecular function of ion channels, mechanism of action of ion channel modulating drugs, and the consequences of dysfunctional electrical signaling in human disease.

Research Focus

Ion channelopathies, ion channel pharmacology, cardiovascular and muscle electrophysiology

Assistant Professor of Pharmacology, RWJMS

Assistant Professor of Medicine, RWJMS

NHLBI K99/R00: Pathway to Independence Award (2020-2025)

American Heart Association Postdoctoral Fellow (2019-2020)

McClenaghan C, Huang Y, Matkovich S, et al. The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. Function (Oxford, England). 2020;1(1):zqaa004. doi:10.1093/function/zqaa004.
McClenaghan C, Huang Y, Yan Z, et al. Glibenclamide reverses cardiovascular abnormalities of Cantu syndrome driven by KATP channel overactivity. The Journal of clinical investigation. 2020;130(3):1116-1121. doi:10.1172/JCI130571.
Smeland M, McClenaghan C, Roessler H, et al. ABCC9-related Intellectual disability Myopathy Syndrome is a K channelopathy with loss-of-function mutations in ABCC9. Nature communications. 2019;10(1):4457. doi:10.1038/s41467-019-12428-7.