McClenaghan Lab

We are interested in how ion channels work, what happens when they break, and how can we fix them? Ion channels are proteins, found in cell membranes, which open and close to allow the movement of charged atoms (ions) into and out of cells. This movement of ions underlies the electrical currents critical for a vast range of biological processes. Your heartbeat, muscles, brain, and the regular function of all your other cells, rely on the precise activities of these ion channels.

When ion channels function abnormally, human disease can arise. We are interested in understanding how ion channels normally work in healthy physiology, how channels behave abnormally in disease, and how dysfunctional ion channels can be targeted therapeutically.

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CABM 324
Study uncovers crucial insights in Ultra-Rare Genetic Syndrome Tied to Potassium Channel Dysfunction
March 18, 2024
Study uncovers crucial insights in Ultra-Rare Genetic Syndrome Tied to Potassium Channel Dysfunction
UCL QUEEN SQUARE INSTITUTE OF NEUROLOGYHome

Read More › about Study uncovers crucial insights in Ultra-Rare Genetic Syndrome Tied to Potassium Channel Dysfunction

Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome
January 13, 2024
Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome
Oxford Academic - BRAIN

Read More › about Novel loss-of-function variants expand ABCC9-related intellectual disability and myopathy syndrome