Dr. Anat Kreimer was awarded an R01 from the National Library of Medicine.
Project narrative:
Deciphering how genetic variation alters the function of regulatory elements remains a central challenge in genomics, as gene regulation underlies nearly all biological processes. To advance our understanding of how these genetic variants disrupt gene regulatory networks (GRNs) which are crucial for understanding disease susceptibility, we propose to develop innovative methods for the reconstruction, analysis and prediction of GRNs, their architecture and components, and making these methods easily accessible to the research community. Our framework will provide a generalizable framework for translating large-scale genomic data into mechanistic insights, advancing our understanding of the gene regulatory code, disease etiology, and applications in precision medicine.