Small Molecules From the Human Microbiota
Associate Professor
Departments of Bioengineering and Microbiology & Immunology
Stanford University
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Download program for the 2020 Shatkin Lecture
Abstract:
The human gut microbiome holds great promise for treating disease, but efforts to engineer it have suffered from the lack of a model system that is complex yet defined. In this talk, I will describe a new set of projects in which we are developing technologies for 1) editing bacterial species from the gut microbiome, and 2) creating highly complex synthetic communities consisting of >100 bacterial species and assaying their structure and function in vitro and in vivo. Early results show marked stability in vitro and following transplantation into the mouse gut, and they suggest a path to fully defined microbiota transplants in humans that are engineered to address a wide range of microbiome-linked diseases.