Education

BS Molecular Biophysics and Biochemistry, Yale University, 2008
PhD Cell Biology, Harvard University, 2014

Bio

Tina Liu is an Assistant Professor at the Department of Molecular Biology and Biochemistry and a resident faculty member of the Center for Advanced Biotechnology and Medicine. She also holds a secondary appointment in the Division of Medical Oncology within the Department of Medicine at Rutgers Robert Wood Johnson Medical School (RWJMS). Her research aims to explore the diverse and complex mechanisms of microbial defense systems, and use these insights to engineer novel tools for health and medicine.

Prior to arriving at Rutgers, Dr. Liu worked as a Senior Scientist at Beam Therapeutics (Cambridge, MA), developing new technologies for genome editing. She also did her postdoctoral research in Dr. Jennifer Doudna’s lab at UC Berkeley, where she defined the nucleic acid targeting preference of Type III CRISPR-Cas complexes and led a multidisciplinary team that developed tandem CRISPR nuclease chemistries for RNA detection and point-of-care diagnostics. She completed her Ph.D. at Harvard University in Dr. Tom Rapoport’s lab, where she investigated the mechanism of membrane fusion in the endoplasmic reticulum.

Research Focus

CRISPR-Cas systems, microbial defense pathways, nucleases, membrane proteins, diagnostics, genome editing, biotechnology

Assistant Professor of Molecular Biology & Biochemistry, SAS

Assistant Professor of Medicine, RWJMS

Jerome and Lorraine Aresty Assistant Professor in Cancer Research

 

Member, Cancer Institute of New Jersey

 

NIH Ruth L. Kirschstein NRSA (F32) Postdoctoral Fellowship, 2016

American Heart Association Postdoctoral Fellowship, 2016 (declined)

National Science Foundation (NSF) Graduate Fellowship, 2010

Chair, Gordon Research Seminar in Molecular Membrane Biology, 2015

Member, Early Career Review (ECR) board at the Journal of Biological Chemistry

1.
Liu T, Knott G, Smock D, et al. Accelerated RNA detection using tandem CRISPR nucleases. Nature chemical biology. 2021;17(9):982-988. doi:10.1038/s41589-021-00842-2.
1.
Liu T, Doudna J. Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation. The Journal of biological chemistry. 2020;295(42):14473-14487. doi:10.1074/jbc.REV120.007034.
1.
Liu T, Liu J-J, Aditham A, Nogales E, Doudna J. Target preference of Type III-A CRISPR-Cas complexes at the transcription bubble. Nature communications. 2019;10(1):3001. doi:10.1038/s41467-019-10780-2.
1.
Liu T, Iavarone A, Doudna J. RNA and DNA Targeting by a Reconstituted Thermus thermophilus Type III-A CRISPR-Cas System. PloS one. 2017;12(1):e0170552. doi:10.1371/journal.pone.0170552.