Education
BA Philosophy, West Virginia University, 2010
BS Biology, West Virginia University, 2010
PhD Molecular and Cellular Biology, Arizona State University, 2015
Bio
Kathy is a Research Associate in the Sleat Lab. She received her Ph.D. in molecular and cellular biology on her work developing recombinant human therapeutic enzymes produced in plant expression systems. Before joining CABM, she completed 6 years of postdoctoral training in Singapore in two different labs. Under the guidance of her first postdoctoral supervisor, Dr. Davis Ng, she studied protein homeostasis in budding yeast. She then continued her training with Dr. Giulia Rancati studying cellular adaptation to essential gene disruption in human cancer cells.
Research Focus
Developing recombinant protein derivatives that can cross the blood brain barrier for the treatment of neurodegenerative lysosomal storage disorders
1.
Larrimore K, Barattin-Voynova N, Reid D, Ng D. Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses. BMC biology. 2020;18(1):117. doi:10.1186/s12915-020-00852-x.
1.
Larrimore K, Kannan L, Kendle P, et al. A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior. Progress in neuro-psychopharmacology & biological psychiatry. 2020;102:109961. doi:10.1016/j.pnpbp.2020.109961.
1.
Zhang S, Xu C, Larrimore K, Ng D. Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation. Cell. 2017;171(2):346-357.e12. doi:10.1016/j.cell.2017.08.036.