Education
BSc, University of Konstanz, 2008
PhD, University of York, 2014
Postdoctoral Researcher, Commissariat à l’Energie Atomique et aux Energies Alternatives (CEA), 2015
Postdoctoral Fellow, European Molecular Biology Laboratory, 2016-2017
Postdoctoral Associate, University of Massachusetts Medical School, 2018-2019
Bio
Jennifer Timm is a structure biologist/biophysicist fascinated by all things protein, always looking for the detailed mechanisms behind nature’s machines. Her scientific career led her to projects involved in drug discovery, drug resistance, histone deposition and metalloproteins. Hooked by the complex mechanisms seen in metalloproteins, she now investigates how at the very origin of life on Earth small peptides started to coordinate metal clusters and catalyze complex chemical reactions nowadays carried out by very complex and big protein machineries.
Research Focus
Evolution of small peptide-metal complexes capable of catalyzing essential metabolic reactions nowadays carried out by complex proteins.
Administrative Appointments
1.
Mancini JA, Pike DH, Poudel S, et al. Design of a Minimal di-Nickel Hydrogenase Peptide. bioRxiv. 2022. doi:10.1101/2022.04.09.487740.
1.
Courouble V V, Dey S, Yadav R, et al. Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics. Journal of the American Society for Mass Spectrometry. 2021;32(7):1618-1630. doi:10.1021/jasms.1c00086.
1.
Timm J, Kosovrasti K, Henes M, et al. Molecular and Structural Mechanism of Pan-Genotypic HCV NS3/4A Protease Inhibition by Glecaprevir. ACS chemical biology. 2020;15(2):342-352. doi:10.1021/acschembio.9b00675.
1.
Timm J, Brochier-Armanet C, Perard J, et al. The CO dehydrogenase accessory protein CooT is a novel nickel-binding protein. Metallomics : integrated biometal science. 2017;9(5):575-583. doi:10.1039/c7mt00063d.