Education
Ph.D. Chemistry, The Australian National University, 2014
Bio
David is a highly motivated and creative researcher specializing in protein chemistry, crystallography, and cryo-electron microscopy. With a strong focus on developing and researching protein targets with crucial implications for the environment and biomedical applications, his ultimate goal is to design next-generation therapeutics. David's expertise is evident in his work as a Research Scientist and Cryo-EM Manager, where he skillfully oversees cryo-EM facility operations and conducts groundbreaking virus/phage-related model reconstructions. His innovative contributions extend to protein purification, structural analysis, and drug screening, showcasing a commitment to advancing the frontiers of science for the betterment of our world.
Research Focus
Virus assembly, drug discovery, cryo-EM
1.
Hou C-F, Swanson N, Li F, Yang R, Lokareddy R, Cingolani G. Cryo-EM Structure of a Kinetically Trapped Dodecameric Portal Protein from the Pseudomonas-phage PaP3. Journal of molecular biology. 2022;434(9):167537. doi:10.1016/j.jmb.2022.167537.
1.
Lokareddy R, Hou C-F, Doll S, et al. Terminase Subunits from the Pseudomonas-Phage E217. Journal of molecular biology. 2022;434(20):167799. doi:10.1016/j.jmb.2022.167799.
1.
Li F, Hou C-F, Yang R, Whitehead R, Teschke C, Cingolani G. High-resolution cryo-EM structure of the virus Sf6 genome delivery tail machine. Science advances. 2022;8(49):eadc9641. doi:10.1126/sciadv.adc9641.
1.
Li F, Hou C-F, Lokareddy R, et al. High-resolution cryo-EM structure of the Pseudomonas bacteriophage E217. Nature communications. 2023;14(1):4052. doi:10.1038/s41467-023-39756-z.