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Probiotic microbes have emerged as potential treatments for a range of diseases, including those affecting the gut as well as other body sites. One such commercially available probiotic is Limosilactobacillus reuteri, which is demonstrated to improve intestinal problems and other conditions including osteoporosis and autism spectrum disorder. In this work, we sought to determine how L. reuteri might be acting to affect such conditions. We narrowed our focus to ask if L. reuteri regulates hormones made in the gut, as gut hormones affect not only the gut but also health across the body. Our results suggest that L. reuteri regulates many human gut hormones like serotonin and other hormones not previously known to be made in the gut like vasopressin. Given that these gut hormones have major effects on the human body, our finding that L. reuteri regulates these hormones may help explain how L. reuteri acts as a probiotic. Building from these findings, we have the potential to better utilize L. reuteri to improve human health.