Designing collagens to shed light on the multi-scale structure–function mapping of matrix disorders

December 23, 2023 • Nanda Lab • Matrix Biology Plus
Collagen synthesis and assembly. Self-assembly in fibrillar collagens from monomers to triple helix to higher-order structures, including fibrils

Dive into the intricate world of collagen research!

Embark on a journey through our most recent review, delving into the essential role of the collagen triple helix structure. Uncover the nuanced impact of single Gly substitutions on folding, structure, biological functions, and mechanical properties. Delve into the exploration of 'designer collagens' as invaluable model systems, shedding light on collagen disorders through a combination of in vitro studies and advanced computational modeling.

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