The project titled: "Defining and Targeting Metabolic Reprogramming in Familial Adenomatous Polyposis" was award ~$500,000 over 3 years.
Familial Adenomatous Polyposis (FAP) is a genetic tumor syndrome in which patients accumulate hundreds to thousands of intestinal tumors, beginning in their early teenage years. The same genetic mutations that cause FAP also give rise to approximately 80% of all human colorectal cancers, making it imperative to understand their molecular consequences in great detail. This project will rigorously and systematically determine how these mutations alter cellular metabolism to promote uncontrolled cell and tumor growth. By understanding the unique metabolic requirements of intestinal tumor cells, we aim to develop new therapeutic approaches for selectively eliminating them while sparing normal cells