Dr. Michael G. Rossmann to Deliver 2018 Aaron J. Shatkin Lecture
The 2018 Aaron J. Shatkin Lecture, "Structural Virology," will be held on Tuesday, October 16th at 4:00PM in the Robert Wood Johnson Medical School Main Lecture Hall, adjacent to CABM. Attendees are invited to a reception in the Great Hall immediately following the lecture.
Michael G. Rossmann graduated from the University of London (B.Sc. (General), 1950; B.Sc. (Special), 1951; M.Sc., 1953) and the University of Glasgow (Ph.D., 1956), after which he was a postdoctoral fellow with Prof. William Lipscomb at the University of Minnesota at Minneapolis (1956-1958) and a Research Associate with Prof. Max Perutz at the MRC Laboratory of Molecular Biology, Cambridge, England (1958-1964). Currently he is the Hanley Distinguished Professor of Biological Sciences at Purdue University, where he has worked as a faculty research scientist since 1964. He is a member of the U.S. National Academy of Sciences, a foreign member of the British Royal Society, and a 2000-2006 member of the National Science Board, the oversight body for the National Science Foundation. He has received numerous international honors and has honorary degrees from universities in Canada, France, Sweden, England, and Belgium.
His laboratory utilizes X-ray crystallography and electron microscopy to study biological structure. His early studies of enzymes at Purdue University recognized a basic protein structure (“fold”) that functions to bind nucleotides. This fold is a component of a large variety of molecules essential for life.
He has also contributed to the technology for the study of biological molecules such as proteins and larger biological molecular assemblies such as viruses. While in Cambridge working with Perutz on the first structure determinations of proteins he helped to develop the isomorphous replacement method and the use of anomalous X-ray dispersion for phase determination. But, most importantly, he invented the Molecular Replacement method which has been used to determine the structures of more than half of the more than 100,000 structures deposited with the international Protein Data Bank.
The driving force behind his interest in technology was his desire to study the structure of viruses and to determine how these molecular assemblages recognize specific hosts, tissues, or cells, how they enter cells and release their genomes and how newly synthesized viral components assemble and mature to form progeny viruses. He has studied single-stranded RNA viruses of plants, as well as human Rhino- (common cold), coxsackie-, polio- and cardio- viruses. Together with his Purdue colleague, Richard Kuhn, he has studied the structures of the enveloped toga- and flaviviruses (including Zika virus); with Colin Parrish (Cornell University) he has studied single-stranded DNA human, canine, feline, and porcine parvoviruses; with Bentley Fane (University of Arizona) he has studied the bacterial ΦX174 virus; and with Dwight Anderson (University of Minnesota), Venigalla Rao (Catholic University of America), Fumio Arisaka (Tokyo Institute of Technology) and Vadim Mesyanzhinov (Moscow University) he has studied the double-stranded DNA tailed f29 and T4 bacteriophages.
The Endowed Aaron J. Shatkin Lectureship
To recognize the scientific achievements and the excellence in science and education fostered by CABM founding director, Aaron Shatkin, an endowed annual lectureship was established in his name and announced at the 25th Anniversary CABM Symposium in October 2011. Dr. Shatkin attended the inaugural lecture, delivered by Dr. Harold Varmus in April 2012.
CABM appreciates the tremendous support expressed for the Aaron J. Shatkin Lectureship and extends our warmest thanks to friends, colleagues and donors to the fund. With your support, the Shatkin Lecture has become a highly anticipated event on campus each spring.
To contribute to the lectureship fund, please visit the Aaron J. Shatkin Lectureship Fund page.